The contraction induced by tetrasodium edetate (EDTA-4Na) in guinea-pig isolated vas deferens kept in isotonic sucrose medium
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Effects of cyclic 3',5'-AMP and related compounds on catecholamine-induced contraction of isolated guinea-pig vas deferens.
Not only cyclic 3'. 5'-AMP but also related compounds containing adeno sine moiety potentiated the contractile response of the isolated guinea-pig vas deferens to catecholamines, especially to dl-isoproterenol. The potentiating activity of cyclic 3', 5'-AMP was one-tenth that of adenosine or 5'-AMP. From these findings, it is suggested that not only adenosine moiety but also the steric conforma...
متن کاملThe effect of ethacrynic acid on the guinea-pig and rat isolated vas deferens.
1 The effect of ethacrynic acid (EA) was studied on guinea-pig and rat vas deferens in vitro.2 EA contracted the guinea-pig but not the rat vas deferens in a dose-dependent manner (50-800 mug/ml). Tyramine caused contraction in 10 out of 18 guinea-pig vas deferens; EA caused contraction in 17 of the preparations which did not respond to tyramine. Repeated doses of EA produced tachyphylaxis, but...
متن کاملEffects of heptanol and carbenoxolone on noradrenaline induced contractions in guinea pig vas deferens.
We examined the effects of two putative gap junction blockers, heptanol and carbenoxolone, on noradrenaline-induced contractions in guinea pig vas deferens. The force generated due to the exogenously added noradrenaline (20 microM) consisted of two components: the tonic and the oscillatory. 2 mM heptanol abolished the oscillatory contractions and drastically suppressed both the maximum force (b...
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Experiments were carried out to examine the effects of protein tyrosine kinase (PTK) and protein tyrosine phosphatase inhibitors on the purinergic contraction of the guinea pig vas deferens. Sodium orthovanadate (SOV) produced a robust increase of the amplitude of contractions evoked by both neurogenic electrical field stimulation and exogenous ATP. This effect of SOV was concentration- and tim...
متن کاملThe accumulation of C14-serotonin in the guinea-pig vas deferens.
Impairment by d-Amphetamine of Delayed Matching Performance in Monkeys. STANLEY D. GLICK AND MURRAY E. JARVIK 1 Behavioral Effects of N,N-Diethyltryptarnine: Absence of Antagonism by Xylamidine Tosylate. J. C. WINTER 7 Narcotic-Antagonist Analgesics : Interactions with Cholinergic Systems. LOUIS S. HARRIS, WILLIAM L. DEWEY, JOHN F. HowEs, JAMES S. KENNEDY AND HARRY PARS 17 Brain Acetylcholine L...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1977
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)66630-8